Is there a link between anxiety and dementia?

Written by Jim Folk
Medically reviewed by Marilyn Folk, BScN.
Last updated July 31, 2024

anxiety and dementia

Is there a link between anxiety and dementia?

Substantial research shows a link between anxiety and an increased risk of developing dementia.[1][2][3][4][5]

Research also shows a link between chronic stress and an increased risk of developing dementia.[6][7][8]

However, research is mixed about the link between elevated cortisol and dementia. For instance, research in 2020 found no link between elevated cortisol and dementia,[6] indicating the dementia link involves other factors, such as emotional responses rather than how cortisol affects the body.

This conclusion seems to be confirmed by recent research that suggests emotional dysregulation, common for anxiety disorder, affects pathological aging, which can increase the risk of developing dementia.[9]

This research suggests emotional dysregulation can adversely affect the posterior cingulate cortex and the amygdala, brain regions heavily involved in managing emotions and autobiographical memory.

Other explanations for the link between anxiety and stress and an increased dementia risk include stress increasing activity in the Emotional Brain, adversely affecting memory (the hippocampus), and suppressing activity in the Rational Brain, the prefrontal cortex (PFC). Since chronic stress can cause ongoing suppression of the (PFC) and atrophy of the hippocampus, this combination could account for the increased risk of developing neuropsychiatric disorders, such as dementia.

Other research[10] suggests that emotional dysregulation and stress shorten telomere length, which can interfere with cellular aging and DNA repair. Anxiety has been linked to shortened telomeres, accelerating aging.

However, other research found a strong link between elevated cortisol and increased dementia risk.[11][12][13]

No matter the specific cause, anxiety is linked to an increased risk of developing dementia, especially in older ages.

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But there is good news!

Research also shows we can mitigate and even reverse the risk by being proactive and changing our lifestyle by:

  • engaging in lifelong learning (which stimulates activity in the PFC and hippocampus);
  • reducing stress and increasing rest and pleasure (which reduces activity in the Emotional Brain and increases PFC and hippocampus activity);
  • regular exercise (which increases blood flow to the brain and improves cardiovascular health);
  • eating a healthy diet of whole natural foods (which aids in the maintenance of a healthy body and brain);
  • regular deep relaxation/meditation (which strengthens the Rational Brain, reduces activity in the Emotional Brain, and reduces the negative effects of stress overall);
  • addressing unhealthy, anxious behavior;
  • learning to manage emotions in healthy ways; and
  • developing a healthy spiritual life (research has shown many physical and mental health benefits associated with a healthy spiritual life,[14] and Christianity in particular[15][16][17][18]).

Since there is a lot we can do to prevent cognitive decline in our elder years, there isn’t any reason to worry.

And based on the research, it’s especially important to work at Level Two recovery since it addresses many factors that can increase the risk of developing dementia. Learning healthy emotional regulation and behaviors that significantly reduce stress can bring benefits beyond just overcoming unhealthy anxiety, including reducing the risk of developing dementia.[19]

Since each of us determines our lifestyle, we have a great say in how our physical and mental health fares over time. Healthy lifestyle changes can make a sizeable difference in the years ahead.

It’s never too soon to live a healthy lifestyle and one that is geared toward living a long and healthy life, especially as we age.

Worry serves no good purpose. Being proactive does.

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The combination of good self-help information and working with an experienced anxiety disorder therapist, coach, or counselor is the most effective way to address anxiety and its many symptoms. Until the core causes of anxiety are addressed – which we call the underlying factors of anxiety – a struggle with anxiety unwellness can return again and again. Dealing with the underlying factors of anxiety is the best way to address problematic anxiety.

Additional Resources

Return to our Anxiety Frequent Questions archive.

anxietycentre.com: Information, support, and therapy for anxiety disorder and its symptoms, including Is there a link between anxiety and dementia?

References

1. Gimson, Amy, et al. “Support for Midlife Anxiety Diagnosis as an Independent Risk Factor for Dementia: a Systematic Review.” BMJ Open, British Medical Journal Publishing Group, 1 Apr. 2018.

2. Santabarbara, Javier, et al. "Does Anxiety Increase the Risk of all-Cause Dementia? An Updated Meta-Analysis of Prospective Cohort Studies." Journal of Clinical Medicine, 9 June 2020.

3. Mortamais, Marion, et al. "Anxiety and 10-Year Risk of Incident Dementia—An Association Shaped by Depressive Symptoms: Results of the Prospective Three-City Study." Frontiers in Neuroscience, 17 April 2018.

4. Stott, Josh, et al. "Associations between psychological intervention for anxiety disorders and risk of dementia: a prospective cohort study using national health-care records data in England." The Lancet - Healthy Longevity, 1 January 2023.

5. Mah, Linda, et al. "Anxiety Symptoms in Amnestic Mild Cognitive Impairment Are Associated with Medial Temporal Atrophy and Predict Conversion to Alzheimer Disease."The American Journal Of Geriatric Psychiatry, 1 May 2015.

6. Sussams, Rebecca, et al. "Psychological stress, cognitive decline and the development of dementia in amnestic mild cognitive impairment." Scientific Reports, 27, Feb 2020.

7. Peavy, Guerry, et al. "The Influence of Chronic Stress on Dementia-Related Diagnostic Change in Older Adults." Alzheimer Disease & Associated Disorders, Sept 2012.

8. Johansson, Lena, et al. "Midlife psychological stress and risk of dementia: a 35-year longitudinal population study." Brain - Oxford Academic, 20 May 2010.

9. Baez-Lugo, Sebastian, et al. “Exposure to negative socio-emotional events induces sustained alteration of resting-state brain networks in older adults.” Nature Aging, 12 January 2023.

10. Bergland, Christopher. "Emotional Distress Can Speed Up Cellular Aging." Psychology Today, 7 April 2014.

11. Holleman, Jasper, et al. "Cortisol, cognition and Alzheimer’s disease biomarkers among memory clinic patients." BMJ Neurology Open, retrieved 30 July 2024.

12. Quanes, Sami, et al. "Persisting neuropsychiatric symptoms, Alzheimer’s disease, and cerebrospinal fluid cortisol and dehydroepiandrosterone sulfate." Alzheimer's Research & Therapy, 19 Dec 2022.

13. Lara, Vivian, et al. "High cortisol levels are associated with cognitive impairment no-dementia (CIND) and dementia." Clinica, Chimica Acta, 23 Aug 2013.

14. Schlundt, David G., et al. “Religious Affiliation and Health Behaviors and Outcomes: Data from the Nashville REACH 2010 Project.Advances in Pediatrics., U.S. National Library of Medicine, 2008.

15. Finlay, Mairi. "Righteousness in the Land of Forgetfulness." Journal of Religion and Health, 30 Jan 2014.

16. Heese, Klaus. "Ageing, dementia and society – an epistemological perspective." SpringerPlus, 20 March 2015.

17. Dein, Simon. "Against the Stream: religion and mental health – the case for the inclusion of religion and spirituality into psychiatric care." British Journal Psych Bulletin - Cambridge University Press, 2 May 2018.

18. Roberts, Nicole. "Science Says: Religion Is Good For Your Health." Forbes - Healthcare.

19. Khaing, Kay, et al. "The effect of anxiety on all-cause dementia: A longitudinal analysis from the Hunter Community Study." Journal of the American Geriatrics Society, 24 July 2024.